The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline was followed to report study findings. The Jadad score was used for evaluating the study quality. Adult patients with either active or latent TB infection were included. Randomized controlled trials (RCTs) that analyzed the effect of DHT interventions on medication adherence outcomes (treatment completion, treatment adherence, missed doses, and noncompleted rate) and treatment outcomes (cure rate and smear conversion) were included. METHODS: A literature search in PubMed and Cochrane databases was conducted. OBJECTIVE: This paper systematically reviews the effect of DHT in improving medication adherence and treatment outcomes in patients with TB. Digital health technology (DHT) seems to be a promising approach to managing problems of nonadherence to medication and improving treatment outcomes. BACKGROUND: Nonadherence to medication in tuberculosis (TB) hampers optimal treatment outcomes.
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